abstract：AIM:The increasing demand for transplantation and the shortage of available organs limit the success of organ transplant programs. The use of marginal donors to expand the donor pool is receiving increased attention. We reviewed a 28-month experience of kidney transplants from marginal donors to assess the impact on pa...

journal_title：Transplantation proceedings

authors： Veroux P,Puliatti C,Veroux M,Cappello D,Macarone M,Puliatti D,Vizcarra D

更新日期：2004-04-01 00:00:00

abstract：:The availability of cadaveric donor organs is insufficient for actual needs. The organ demand increases by 20% per year. Living donor transplant (LDT) may be a valid therapeutical alternative provided one uses proper criteria. LDT provides many advantages, like improved patient and organ survival, short waiting time, ...

journal_title：Transplantation proceedings

authors： Splendiani G,Cipriani S,Valeri M,Torlone N,Vega A,Tullio T,Condò S,Dominijanni S,Casciani CU

更新日期：2004-04-01 00:00:00

abstract：:In Italy, health-care telematic is funded and supported at the level of national government or regional institutions. In 1999, the Italian Ministry of Health started to fund the Liguria-Trento Transplant Network (LTTN) project, a health research project with the aim to build an informative system for donor management ...

journal_title：Transplantation proceedings

authors： Valente R,Cambiaso F,Santori G,Ghirelli R,Gianelli A,Valente U

更新日期：2004-04-01 00:00:00

abstract：:Mycophenolate mofetil (MMF), in combination with cyclosporine and corticosteroids, improves long-term graft survival in renal transplant recipients. However, optimal MMF therapy may be limited by gastrointestinal (GI) intolerance, which may result in the need for MMF dose reduction, interruption, or discontinuation, l...

journal_title：Transplantation proceedings

authors： Nashan B,Ivens K,Suwelack B,Arns W,Abbud Filho M,myPROMS DE02 Study Group.,LA01 Study Group.

更新日期：2004-03-01 00:00:00

abstract：:Therapeutic drug monitoring of cyclosporine has been established as part of the routine clinical treatment for patients after organ transplantation. The inability to define optimal dose (maximize efficacy/minimize toxicity) has been a problem related to drug monitoring of cyclosporine. The original cyclosporine formul...

journal_title：Transplantation proceedings

authors： Midtvedt K

更新日期：2004-03-01 00:00:00

abstract：:Early attempts to perform successful allogeneic hematopoietic stem cell transplants were plagued by graft rejection and graft-versus-host disease, leading many investigators to lose hope that bone marrow transplantation could ever become a useful therapeutic approach in clinical medicine. Although many subsequent disc...

journal_title：Transplantation proceedings

authors： Hogan WJ,Storb R

更新日期：2004-03-01 00:00:00

abstract：:The introduction of cyclosporine into clinical practice of thoracic organ transplantation had a dramatic and positive effect on both short- and long-term survival. Today, the majority of patients are still treated with this drug, and different immunosuppressive combination therapies have further resulted in improved l...

journal_title：Transplantation proceedings

authors： Haverich A,Gorler H

更新日期：2004-03-01 00:00:00

abstract：:Immunosuppressive regimens in the early precyclosporine days of liver transplantation for the Cambridge-King's Programme from 1968 until the early 1980s were inadequate in the control of rejection. The consequent use of high-dose steroids led to many infections, which seriously affected outcome. Nevertheless, occasion...

journal_title：Transplantation proceedings

authors： Williams R

更新日期：2004-03-01 00:00:00

abstract：:Ten-year graft survival rate was 89% after immunosuppressive therapy with cyclosporine, methylprednisolone, and mizoribine in pediatric renal transplant recipients enrolled in our multicenter study. Adrenocorticosteroids, which cause growth retardation, were reduced by administration on alternate days in 67% and withd...

journal_title：Transplantation proceedings

authors： Hasegawa A,Motoyama O,Shishido S,Ito K,Tsuzuki K,Takahashi K,Ohshima S

更新日期：2004-03-01 00:00:00

abstract：:Since 1983, cyclosporine has been the backbone of immunosuppression in clinical organ transplantation. Cyclosporine is usually used in combination with steroids and with another second-line immunosuppressant like azathioprine or mycofenolate mofetil. With these regimens, graft survival at 1 year exceeds 90% and long-t...

journal_title：Transplantation proceedings

authors： Kyriakides G,Miller J

更新日期：2004-03-01 00:00:00

abstract：:Cyclosporine (CsA) is currently the basis of most immunosuppressive protocols after solid organ transplantation. The introduction of Neoral, a new microemulsion formulation of CsA, and more recently a range of adjunctive immunosuppressants have further enhanced short-term efficacy and tolerability of CsA-based immunos...

journal_title：Transplantation proceedings

authors： Hernández D

更新日期：2004-03-01 00:00:00

abstract：:Several groups have performed graft biopsies at set times posttransplant ("protocol biopsies") and found unequivocal histologic criteria for acute rejection in a high proportion of patients with stable graft function. The significance of "subclinical" rejection remains controversial. Our group and others have shown th...

journal_title：Transplantation proceedings

authors： Rush D,Winnipeg Transplant Group.

更新日期：2004-03-01 00:00:00

abstract：:In this short review I show how cyclosporine fits into the broader picture of immunosuppression for organ allografting. Before cyclosporine there were some good results, particularly in kidney grafting, but also a failure rate of 50% of grafts by 1 year. Cyclosporine changed the graft survival of 1 year to 80%, althou...

journal_title：Transplantation proceedings

authors： Calne R

更新日期：2004-03-01 00:00:00

abstract：:Patients suffering irreversible loss of intestinal function require total parenteral nutrition (TPN). During long-term TPN, catheter infections are a common problem and intestinal transplantation (ITx) is indicated when patients experience loss of venous access. We report two patients with short bowel syndrome--one be...

journal_title：Transplantation proceedings

authors： Braun F,Platz KP,Faendrich F,Kremer B,Mueller AR

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:In our previous study, blood levels of orally administered tacrolimus were significantly higher in short bowel piglets than in control animals. It has been reported that the blood levels of tacrolimus are influenced by the metabolic activity of intestinal CYP3A4. If tacrolimus may be absorbed in the colon, dire...

journal_title：Transplantation proceedings

authors： Nishi K,Ishii T,Wada M,Amae S,Sano N,Nio M,Hayashi Y

更新日期：2004-03-01 00:00:00

abstract：:Acute cellular rejection remains a serious and frequent complication during the posttransplant course of small bowel allograft recipients. Currently, small bowel biopsies are the optimal method to identify this form of rejection. The morphological criteria for this diagnosis have been known for some time; however, no ...

journal_title：Transplantation proceedings

authors： Ruiz P,Bagni A,Brown R,Cortina G,Harpaz N,Magid MS,Reyes J

更新日期：2004-03-01 00:00:00

abstract：:There is some evidence that portal venous drainage may offer immunologic and metabolic advantages in small bowel transplantation. Isolated small bowel transplantation was performed in 14 adult patients. In all cases, the donor pancreas was transplanted into another patient. During the donor procedure, the superior mes...

journal_title：Transplantation proceedings

authors： Platz KP,Pascher A,Braun F,Fändrich F,Neuhaus P,Kremer B,Mueller AR

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Intestinal ischemia-reperfusion injury (IRI) represents an exaggerated inflammatory cascade with a complex pathophysiology. IL-2, IL-6, HSP70, and INF-gamma are mediators of the inflammatory process. Therefore, we investigated their kinetics and localization during intestinal IRI. METHODS:Pig intestinal spe...

journal_title：Transplantation proceedings

authors： Braun F,Hosseini M,Wieland E,Sattler B,Müller AR,Fändrich F,Kremer B,Ringe B

更新日期：2004-03-01 00:00:00

abstract：:This paper discusses the commonly seen complications encountered in Middle Eastern transplant recipients, including posttransplant Kaposi's sarcoma, tuberculosis, infective diarrhea, and pregnancy. ...

journal_title：Transplantation proceedings

authors： Al-Khader AA,Shaheen FA

更新日期：2004-01-01 00:00:00

abstract：:The aim of this study was to identify the characteristics of coronary heart disease (CHD) in renal transplant recipients as well as to assess the impact of coronary angiography on allograft function. The 21 cases including 2 women and 19 men who underwent coronary angiography were retrospectively studied for age at tr...

journal_title：Transplantation proceedings

authors： Pirat B,Müderrisoglu H,Korkmaz ME,Ozin B

更新日期：2004-01-01 00:00:00

abstract：:Ovarian dysfunction, anovulatory vaginal bleeding, amenorrhea, high prolactin levels, and loss of libido are the causes of infertility in women with chronic renal failure. After renal transplantation, endocrine function generally improves after recovery of renal function. In this study we retrospectively evaluated the...

journal_title：Transplantation proceedings

authors： Başaran O,Emiroğlu R,Seçme S,Moray G,Haberal M

更新日期：2004-01-01 00:00:00

abstract：:CD44 is a type I transmembrane glycoprotein serving as a cell adhesion receptor, whose main ligand is hyaluronic acid, but also may interact with collagen, laminin, fibronectin, and osteopontin. This marker is involved in cell migration, homing, activation, metastasis, and inflammation. Tubular CD44 expression has bee...

journal_title：Transplantation proceedings

authors： Sarioğlu S,Sis B,Tuncer C,Celik A,Zeybel M,Soylu A,Gülay H

更新日期：2004-01-01 00:00:00

abstract：:Erectile dysfunction (ED) is more frequent among end-stage renal failure patients than the normal population. Sildenafil citrate has been successfully used for the symptomatic treatment of erectile dysfunction. The aim of this study was to determine the efficacy and safety of sildenafil citrate in the treatment of ED ...

journal_title：Transplantation proceedings

authors： Sahin Y,Aygün C,Peşkircioğlu CL,Kut A,Tekin MI,Ozdemir FN,Ozkardeş H

更新日期：2004-01-01 00:00:00

abstract：:While solid organs represent the dramatic and lifesaving aspect of donation after death, the transplantation of tissues from donors after death is a much larger-scale activity that benefits enormous numbers of patients, usually in a life-enhancing rather than a lifesaving manner. Some types of tissue transplantation, ...

journal_title：Transplantation proceedings

authors： Yücetin L,Keçecioğlu N,Ozenci AM,Söğüncü Y,Islamoğlu K,Ersoy FF

更新日期：2004-01-01 00:00:00

abstract：:To evaluate the postoperative complications within the first month among 20 pediatric liver transplant recipients between April 1990 and March 2003 we retrospectively studied their medical charts to gather demographic data; primary diagnosis; operative duration; perioperative transfusions; time to extubation; length o...

journal_title：Transplantation proceedings

authors： Araz C,Pirat A,Torgay A,Zeyneloglu P,Arslan G

更新日期：2004-01-01 00:00:00

abstract：AIM:The pattern of rejection of vascularized pancreas allografts in presensitized recipients was studied among congeneic and recombinant rat strains in order to establish the time frame of rejection. Donors and recipients differed either in their entire MHC or in class I or class II MHC antigens. MATERIAL AND METHODS:...

journal_title：Transplantation proceedings

authors： Litmathe J,Bektas H,Jörns A,Klempnauer J

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the regenerative potential of hyaline cartilage in a neocartilage graft implant with the aid of MR cartilage imaging using a rabbit model. METHODS:Surgical osteochondral defects were created in the femoral condyles of 30 mature New Zealand rabbits. The findings o...

journal_title：Transplantation proceedings

authors： Tan CF,Ng KK,Ng SH,Cheung YC

更新日期：2003-12-01 00:00:00

abstract：:In human heart and kidney transplantations, granzyme B (GrB) and perforin have both been shown to be predictive markers for acute cellular rejection (ACR). We investigated the tissue expression and possible relationship of GrB and perforin to the clinical outcome, histopathology, and function of intestinal transplants...

journal_title：Transplantation proceedings

authors： D'Errico A,Corti B,Pinna AD,Altimari A,Gruppioni E,Gabusi E,Fiorentino M,Bagni A,Grigioni WF

更新日期：2003-12-01 00:00:00

abstract：UNLABELLED:Calcineurin inhibitor-related renal toxicity affects patient and graft survival in transplant recipients. Our clinical experience has revealed sirolimus to be an effective agent in treating renal insufficiency related to calcineurin inhibitor toxicity. METHODS:We performed a retrospective review of the medi...

journal_title：Transplantation proceedings

authors： Neff GW,Montalbano M,Slapak-Green G,Meyer D,Berney T,Safdar K,Schiff ER,Tzakis AG

更新日期：2003-12-01 00:00:00

abstract：:The organ allocation system for liver transplantation was recently changed to address criticisms that it was too subjective and relied too heavily on total waiting time. The new system, Model for End-Stage Liver Disease and Pediatric Model for End-Stage Liver Disease (MELD/PELD), stratifies patients based on the risk ...

journal_title：Transplantation proceedings

authors： Aggarwal A,Ong JP,Goormastic M,Nelson DR,Arroliga AC,Farquhar L,Mayes J,Younossi ZM

更新日期：2003-12-01 00:00:00

abstract：:Preservation injury (PI) is defined as hepatic dysfunction that occurs within 10 days of liver transplantation (OLT) but spontaneously resolves. However, we noted two new patterns: one characterized by histologic evidence of preservation injury that occurs at later than 10 days post-OLT (late PI), and a second, of per...

journal_title：Transplantation proceedings

authors： Lee YM,O'Brien CB,Yamashiki N,Behro M,Weppler D,Tzakis AG,Schiff ER

更新日期：2003-12-01 00:00:00

abstract：:Gastric emptying time (GET) appears to be a rate-limiting factor in the absorption of cyclosporine-A (CsA) and may be responsible for intra- and interpatient variability of CsA bioavailability. Few studies have assessed gastric motility after renal transplantation. The purpose of this study was to evaluate gastric emp...

journal_title：Transplantation proceedings

authors： Ozkaya O,Derici U,Buyan N,Dalgic A,Dalgic B,Cingi E,Kitapci M,Sindel S,Hasanoglu E

更新日期：2003-12-01 00:00:00

abstract：:The purpose of our report is to present the long-term outcomes of three renal transplant recipients with high-grade stenosis and suboptimal percutaneous angioplasty (PTA) because of technical difficulties. Two men and one woman of age 67, 53, and 54 years, who maintained functional cadaveric graft for 17, 9, and 13 ye...

journal_title：Transplantation proceedings

authors： Buturović-Ponikvar J,Ponikvar R

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:This study evaluates the impact of living renal donors (LD) aged 60 years and older on graft performance and patient survival in an old-for-young constellation. PATIENTS AND METHODS:We analyzed 144 consecutive LDs between January 1983 and December 2002 (19 patients 60+/125 controls). RESULTS:Mean donor age in...

journal_title：Transplantation proceedings

authors： Giessing M,Slowinski T,Deger S,Tuerk I,Schönberger S,Budde K,Loening SA

更新日期：2003-12-01 00:00:00

abstract：UNLABELLED:An open, single arm, prospective clinical trial to assess the efficacy and safety of basiliximab (Simulect) combined with cyclosporine microemulsion (Neoral), steroids, and azathioprine was performed in four centers in Chile, two adult and two pediatric. The 23 patients who were enrolled were followed for 12...

journal_title：Transplantation proceedings

authors： Mocarquer A,Pinto V,Buckel E,Lagos E,Pefaur J,Ramirez K,Morales J,Rosatti P,Elberg A,Simulect Multicenter Study Group of Chile.

更新日期：2003-11-01 00:00:00

abstract：:The blockade of costimulatory signals is a powerful strategy to prevent allograft rejection and facilitate transplantation tolerance. In recent years, a series of novel costimulatory molecules have been identified, including an inducible costimulatory molecule (ICOS). To date, little has been uncovered regarding the t...

journal_title：Transplantation proceedings

authors： Nanji SA,Hancock WW,Anderson CC,Zhu LF,Kneteman NM,Shapiro AM

更新日期：2003-11-01 00:00:00

abstract：AIM:Most technical complications after orthotopic liver transplantation (OLT) are related to the biliary tree. This report reviews the role of routine intraoperative placement of stents to reduce biliary complications. METHODS:We retrospectively analyzed 396 consecutive OLTs. We reviewed rates of biliary complications...

journal_title：Transplantation proceedings

authors： Barkun JS,Tzimas GN,Cantarovich M,Metrakos PP,Deschênes M,Alpert E,Paraskevas S,Tchervenkov JI

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Organ transplantation is the preferred treatment for end-stage renal disease. Renal transplant recipients are surviving longer with a better quality of life. Although many hospitals have transplant education programs in place, transplant patients indicate that there is a need for additional information. Tran...

journal_title：Transplantation proceedings

authors： Sharkey C,Gourishankar S

更新日期：2003-11-01 00:00:00

abstract：:Clinical cell transplantation remains as a clinical experiment. Morphologically intact and functional cells transplanted into their tissue of origin undergo rapid disintegration by attacking granulocytes and macrophages, leading to the so-called early graft dysfunction. When transplanted to sites remote from their ori...

journal_title：Transplantation proceedings

authors： Olszewski WL

更新日期：2003-09-01 00:00:00

abstract：:The aim of this study was to compare cardiomyocytes and stromal pathology in heart transplant recipients treated with rapamycin (RAPA) versus cyclosporine (CyA). We analyzed elective biopsies obtained during first 3 months after heart transplantation in four patients treated with RAPA (24 biopsies) and seven patients ...

journal_title：Transplantation proceedings

authors： Zakliczynski M,Nozynski J,Swierad M,Konecka-Mrowka D,Zembala M

更新日期：2003-09-01 00:00:00